Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses
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چکیده
منابع مشابه
Heavy/Light-chain analysis of monoclonal gammopathies.
Monoclonal gammopathies (M proteins) are associated with an extraordinarily broad array of clinical conditions that range from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma. Three basic goals of the methods used to investigate M proteins are detection, immunochemical characterization, and quantification. Serum protein electrophoresis (SPE) techniques have undergo...
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The nested polymerase chain reaction (PCR) method was used for the amplification of the influenza A H1N1 virus hemagglutinin monoclonal antibody light-chain and heavy-chain genes. Sequence analysis of the obtained genes was then used to identify common cloning methods of the mouse immunoglobulin-kappa (Igκ) light-chain and heavy-chain variable gene regions. Twenty-two pairs of amplification pri...
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ژورنال
عنوان ژورنال: Cell Discovery
سال: 2019
ISSN: 2056-5968
DOI: 10.1038/s41421-019-0086-x